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Applied - Medicine

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Most Expensive Prescription Drugs

This list features the most expensive prescription drugs based on annual treatment costs as of 2022.

RANK

DRUG

ANNUAL TREATMENT COST

MANUFACTURER

DESCRIPTION

1

Zolgensma

$2,125,000

Novartis (Switzerland)

A gene therapy for spinal muscular atrophy (SMA), a genetic disorder affecting muscle strength.

2

Zokinvy

$1,032,480

Eiger BioPharmaceuticals (USA)

Treatment for progeria, a rare genetic condition causing rapid aging in children.

3

Luxturna

$850,000

Novartis (Switzerland)

Gene therapy for Leber congenital amaurosis, a rare genetic disease causing blindness.

4

Ravicti

$794,000

Horizon Pharma GmbH (Germany)

Used for treating urea cycle disorders, which prevent the body from removing ammonia.

5

Carbaglu

$790,000

Recordati (Italy)

A treatment for acute hyperammonemia in patients with certain urea cycle disorders.

6

Soliris

$700,000

Alexion Pharmaceuticals Inc. (USA)

A complement inhibitor used to treat various rare blood disorders, including PNH and aHUS.

7

Brineura

$700,000

BioMarin Pharmaceutical Inc. (USA)

Enzyme replacement therapy for Batten disease, a rare neurodegenerative disorder in children.

8

Elaprase

$657,000

The Shire (Ireland)

Enzyme replacement therapy for Hunter syndrome, a genetic disorder affecting metabolism.

9

Lumizyme

$520,000

Sanofi Genzyme (USA)

Treatment for Pompe disease, a rare genetic disorder that affects muscle function.

10

Spinraza

$375,000

Biogen (USA)

An antisense oligonucleotide used to treat spinal muscular atrophy (SMA).


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References

Pharmaoffer. (2025). 10 most expensive drugs in the world. Available at: https://pharmaoffer.com/blog/10-most-expensive-drugs-in-the-world/ (Accessed 1 December 2025).
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