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SCIENCE

Applied - Medicine
Most Commonly Prescribed Medications
This list features the most commonly prescribed medications in the USA in 2022.
RANK | MEDICATION | TOTAL PRESCRIPTIONS | TOTAL PATIENTS |
1 | Atorvastatin | 109,582,746 | 27,935,702 |
2 | Metformin | 86,747,907 | 19,536,027 |
3 | Lisinopril | 82,513,967 | 20,314,304 |
4 | Levothyroxine | 82,431,914 | 18,130,331 |
5 | Amlodipine | 70,766,211 | 17,789,649 |
6 | Metoprolol | 65,245,216 | 15,542,999 |
7 | Albuterol | 59,075,269 | 19,265,334 |
8 | Losartan | 53,555,510 | 13,150,031 |
9 | Omeprazole | 52,132,950 | 13,802,111 |
10 | Gabapentin | 40,141,486 | 9,889,546 |
References
ClinCalc. (2024). The Top 300 Drugs of 2022. Available at: https://clincalc.com/DrugStats/Top300Drugs.aspx (Accessed 1 December 2025).

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