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HISTORY

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Disease

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Diseases with the Highest Mortality Rates

This list features the diseases with the highest mortality rates.

RANK

DISEASE

MORTALITY RATE

1

Mad Cow Disease

100%

2

Rabies

100%

3

Balamuthia Encephalitis

98%

4

Brain-eating Amoeba

95%

5

Nipah Virus

75%

6

Bird Flu

60%

7

Hendra Virus

57%

8

Marburg Virus

50%

9

Ebola Virus

50%

10

African Sleeping Sickness

42.5%

11

Monkey B Virus

42%

12

Glanders

40%


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References

CBS News (2023) Deadly diseases: Infectious world ranked. Available at: https://www.cbsnews.com/pictures/deadly-diseases-infectious-world-ranked/60/ (Accessed 1 December 2025).
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